Improving survival rates for adolescents and young adults with cancer.
Approximately 43,000 men and women were diagnosed with leukemia in the United States in 2009. The disease is unique in that it is common in both pediatric (<15) cancer patients and in older adult (>60) cancer patients. Of those diagnosed with leukemia, approximately 2600, or six percent, were diagnosed as adolescents or young adults (AYAs). Although there have been vast improvements in survival rates especially for pediatric leukemia, AYAs have not seen these same advancements. AYAs are often caught in the gap between pediatrics and adult cancers and different outcomes were seen in comparing treatments based on pediatric protocols versus adult protocols. Overall, adolescents treated on more aggressive pediatric protocols had improved overall and event-free survival.
Source: Advani A, Hunger S, Burnett A, Acute Leukemia in Adolescents and Young Adults. Semin Oncol. 2009; 36:213-226.
Outcomes of allogeneic hematopoietic cell transplantation for adolescent and young adults compared to children and older adults with acute myeloid leukemia.
Biol Blood Marrow Transplant. 2011 Oct 28;
Authors: Majhail NS, Brazauskas R, Hassebroek A, Bredeson CN, Hahn T, Hale GA, Horowitz MM, Lazarus HM, Maziarz RT, Wood WA, Parsons SK, Joffe S, Douglas Rizzo J, Lee SJ, Hayes-Lattin BM
Abstract
PURPOSE: Adolescents and young adults (AYAs) with cancer have not experienced improvements in...
Clinical Trial Participation and Time to Treatment Among Adolescents and Young Adults With Cancer: Does Age at Diagnosis or Insurance Make a Difference?
J Clin Oncol. 2011 Sep 19;
Authors: Parsons HM, Harlan LC, Seibel NL, Stevens JL, Keegan TH
Abstract
PURPOSEBecause adolescent and young adult (AYA) patients with cancer have experienced variable improvement in survival over the past two decades, enhancing the quality and timeliness of cancer care in this population has emerged as a...
Adolescents with acute lymphoblastic leukaemia: emerging from the shadow of paediatric and adult treatment protocols.
Pediatr Blood Cancer. 2006 Nov;47(6):748-56
Authors: Ramanujachar R, Richards S, Hann I, Webb D
Adolescents and young adults (AYA) with acute lymphoblastic leukaemia (ALL) constitute a distinct population from children and older adults. Based on patterns of referral, they may be treated by either paediatric or adult oncologists. As a group, AYA with ALL have a worse survival and...
[Conversion of acute leukemia from a T-lymphoid to a myeloid phenotype].
Rinsho Ketsueki. 1989 Dec;30(12):2163-8
Authors: Sugita K, Nakazawa S, Saito M, Gonda T, Kusumoto Y, Aya M, Osano M, Shimizu M, Okazaki T, Inaba T
A 7-year-old girl with an acute leukemia was reported whose blasts showed conversion from a T-lymphoid to a myeloid phenotype. At the onset of the disease, the blasts were negative for peroxidase and displayed FAB L1 morphology. Surface marker analysis revealed only CD7 antigen....
[Monocytic crisis in chronic myeloid leukemia: a case report].
Rinsho Ketsueki. 1989 Mar;30(3):376-81
Authors: Sugita K, Nakazawa S, Mori T, Nishino K, Abe T, Gonda T, Aya M, Osano M, Takane K, Okazaki T
We report a 17-year-old female with chronic myeloid leukemia (CML) who developed monocytic crisis. She was diagnosed as chronic phase of Ph1-chromosome positive CML at 14 years old. Three years after the diagnosis of the disease, she was admitted to the hospital because of low grade fever, lethargy...
Establishment and characterization of Ph1-positive and Ph1-negative lymphoblastoid cell lines from a patient with chronic myelogenous leukemia.
Jpn J Cancer Res. 1985 May;76(5):365-73
Authors: Yamada T, Sasaki M, Yoshida MC, Aya T, Koizumi S, Osato T
Two continuously growing in vito cell lines, PB-1049 and LN-1049, were established from a patient with Ph1-positive chronic myelogenous leukemia in extramedullary blastic crisis. PB-1049 was established from Epstein-Barr virus (EBV)-infected peripheral...
A tiger mouse and relatives. Variants caused by an activated transposable element?
J Hered. 1984 Jan-Feb;75(1):2-7
Authors: Wallace ME, Nash HR
In a laboratory-bred population of wild Peruvian house mice, one male had an excessive rate of non-pairing of the X and Y chromosomes. After crossing him with laboratory stock mice, a mouse of very unusual phenotype appeared from a yellow (AyA) mother. He was yellow with black dorsal stripes; hence Tiger. He was mated to many females, and inbred F2 and F3...
Interaction between Epstein-Barr virus and type-C virus in human cells.
IARC Sci Publ. 1978;(20):413-20
Authors: Osato T, Yamamoto K, Matsuo T, Aya T, Mizuno F, Nonoyama M
The interaction between EBV and type-C viruses was studied in our FVNC experimental system, in which EBV and type-C viral genomes are contained in each cell. The data indicate that the human lymphoid FVNC cells are sensitive to both EBV and type-C virus exposure, showing high frequencies of induction of both repressed viral...
Dual persistence of Epstein-Barr viral and type-C viral genomes in nonproducer human lymphoblastoid cells.
Bibl Haematol. 1975;(40):585-8
Authors: Osato T, Yamamoto K, Mizuno F, Sugawara K, Aya T
PMID: 169826 [PubMed - indexed for MEDLINE]
Adolescent and young adult (AYA) oncology: the first A.
Pediatr Hematol Oncol. 2007 Jul-Aug;24(5):325-36
Authors: Bleyer A
Whereas adolescents with cancer as a group used to have a better prognosis than children with malignant disease, trends suggest that the overall survival of 15- to 19-year-olds is now worse than in younger patients. Also, the incidence of cancer is higher in 15- to 19-year age span than during the first 15 years of life. In 2006, the U.S. National Cancer Institute (NCI) and the...
Challenges in the recruitment of adolescents and young adults to cancer clinical trials.
Cancer. 2007 Dec 1;110(11):2385-93
Authors: Burke ME, Albritton K, Marina N
The adolescent and young adult (AYA) oncology population has seen inferior progress in cancer survival compared with younger children and older adults over the past 25 years. Previously, AYAs had the best survival rates due to the prevalence of highly curable diseases including Hodgkin lymphoma and germ cell tumors, yet today AYAs have...
Diversity of T-cell receptor gene rearrangements in South Indian patients with common acute lymphoblastic leukemia.
Iran J Immunol. 2009 Sep;6(3):141-6
Authors: Sudhakar N, Nancy NK, Rajalekshmy KR, Rajkumar T
Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) occurs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a particular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic...
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