Improving survival rates for adolescents and young adults with cancer.
Hodgkin lymphomas (HL) and Non-Hodgkin Lymphomas (NHL) represent 13% of total cancer diagnoses in the adolescent and young adult (AYA) population ages 15-39. Even though we continue to learn more and more about the general histological and molecular characteristics of NHL and HL, we are still lacking knowledge based on the unique biology of lymphomas in the AYA population as compared to the better understanding gained in the younger and older populations. To address psychosocial and treatment based issues in this age group it is important to examine the use of age-directed reviews of patients whether this is through retrospective or prospective studies.
Source: Jaglowski S, Linden E, Termuhlen A et al. Lymphoma in Adolescents and Young Adults. Semin Oncol. 2009; 36:381-418.
Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphoma.
Leuk Res. 2011 Jun;35(6):787-92
Authors: Kita A, Nakahara T, Yamanaka K, Nakano K, Nakata M, Mori M, Kaneko N, Koutoku H, Izumisawa N, Sasamata M
Abstract
YM155, a novel small-molecule that down-regulates survivin, exhibits broad, potent antitumor activity against a range of human tumors. We evaluated the activity of YM155 in aggressive non-Hodgkin lymphoma. In a number of diffuse...
Clinical trial participation and time to treatment among adolescents and young adults with cancer: does age at diagnosis or insurance make a difference?
J Clin Oncol. 2011 Oct 20;29(30):4045-53
Authors: Parsons HM, Harlan LC, Seibel NL, Stevens JL, Keegan TH
Abstract
PURPOSE: Because adolescent and young adult (AYA) patients with cancer have experienced variable improvement in survival over the past two decades, enhancing the quality and timeliness of cancer care in this population...
Optimal therapy for acute lymphoblastic leukemia in adolescents and young adults.
Nat Rev Clin Oncol. 2011 Jul;8(7):417-24
Authors: Schafer ES, Hunger SP
Abstract
Although the survival rate for adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) has steadily improved over the past several decades, it still lags behind that of younger children. This Review explores the reasons for this discrepancy and potential solutions, focusing on patients aged 15-22 years....
Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes.
Lancet. 1991 May 18;337(8751):1190
Authors: Aya T, Kinoshita T, Imai S, Koizumi S, Mizuno F, Osato T, Satoh C, Oikawa T, Kuzumaki N, Ohigashi H
Dual exposure to Epstein-Barr virus and purified 4-deoxyphorbol ester derived from the plant Euphorbia tirucalli induced a high frequency of chromosomal rearrangements in human B lymphocytes in vitro. Rearrangements most commonly affected chromosome...
An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA.
Virus Genes. 1991 Apr;5(2):147-56
Authors: Takada K, Horinouchi K, Ono Y, Aya T, Osato T, Takahashi M, Hayasaka S
An Epstein-Barr virus (EBV)-producer line, designated Akata, was established from a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type chromosome translocation, t(8q- ; 14q+), and was derived from the tumor cell. Akata cells produced a large quantity of...
Epstein-Barr virus, Burkitt's lymphoma, and an African tumor promoter.
Adv Exp Med Biol. 1990;278:147-50
Authors: Osato T, Imai S, Kinoshita T, Aya T, Sugiura M, Koizumi S, Mizuno F
PMID: 1963031 [PubMed - indexed for MEDLINE]
[Conversion of acute leukemia from a T-lymphoid to a myeloid phenotype].
Rinsho Ketsueki. 1989 Dec;30(12):2163-8
Authors: Sugita K, Nakazawa S, Saito M, Gonda T, Kusumoto Y, Aya M, Osano M, Shimizu M, Okazaki T, Inaba T
A 7-year-old girl with an acute leukemia was reported whose blasts showed conversion from a T-lymphoid to a myeloid phenotype. At the onset of the disease, the blasts were negative for peroxidase and displayed FAB L1 morphology. Surface marker analysis revealed only CD7 antigen....
African Burkitt's lymphoma and an Epstein-Barr virus-enhancing plant Euphorbia tirucalli.
Lancet. 1987 May 30;1(8544):1257-8
Authors: Osato T, Mizuno F, Imai S, Aya T, Koizumi S, Kinoshita T, Tokuda H, Ito Y, Hirai N, Hirota M
PMID: 2884382 [PubMed - indexed for MEDLINE]
Epstein-Barr virus-enhancing plant promoters in east Africa.
AIDS Res. 1986 Dec;2 Suppl 1:S151-5
Authors: Mizuno F, Osato T, Imai S, Koizumi S, Aya T, Kinoshita T, Hirai N, Hirota M, Ohigashi H, Koshimizu K
The extracts of a certain African plant species, Euphorbia tirucalli, were found to have markedly enhancing effects on the activation of latent Epstein-Barr virus (EBV) genomes in the EBV carrying lymphoblastoid cells and also on EBV-induced transformation of human lymphocytes. The Euphorbia...
Epstein-Barr virus infection and oncogenesis in primary immunodeficiency.
AIDS Res. 1986 Dec;2 Suppl 1:S115-9
Authors: Okano M, Osato T, Koizumi S, Imai S, Aya T, Fujiwara S, Mizuno F, Sakiyama Y, Matsumoto S, Sugawara O
Lymphomas occurred in 3 of 16 Japanese patients with ataxia telangiectasia (AT) and Wiskott-Aldrich syndrome (WAS). The patients had a persistently reactivated Epstein-Barr virus (EBV) infection with a remarkable decrease in virus-specific cellular immunity. In these patients, the...
Evolution of infectious mononucleosis into Epstein-Barr virus carrying monoclonal malignant lymphoma.
Lancet. 1982 Jun 5;1(8284):1272-6
Authors: Abo W, Takada K, Kamada M, Imamura M, Motoya T, Iwanga M, Aya T, Yano S, Nakao T, Osato T
A monoclonal malignant lymphoma was diagnosed in a 30-month-old Japanese boy, who, since the age of 12 months, had had chronic, recurrent infectious mononucleosis manifested by repeated episodes of severe cough and high fever accompanied by marked lymphadenopathy and...
Early events in transformation of human cord leukobytes by Epstain-Barr virus: induction of DNA synthesis, mitosis and the virus-associated nuclear antigen synthesis.
Int J Cancer. 1974 Sep 15;14(3):341-7
Authors: Aya T, Osato T
PMID: 4376517 [PubMed - indexed for MEDLINE]
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